Patient-drug precision matching

STALICLA's DEPI technology uses advanced AI analysis to identify patient subgroups with similar disease signatures. It integrates and analyzes large omics data sets, including genomics, transcriptomics, proteomics, pharmacogenomics, and clinical data. DEPI then matches these subgroups with a tailored NDD-targeted drug or drug combination, validated using patient cells, to provide a precision medicine solution.

DEPI's unique drug-patient matching module is accelerating our drug development pipeline. It has achieved clinical proof of concept with the validation of Phenotype 1, supported by studies at Greenwood Genetic Center and Cincinnati Children's Hospital. We have also validated a second ASD subgroup, Phenotype 2 with matching drug candidate STP2. STP1 will advance to phase 2 trials in 2025.

How does DEPI work?

1.

Mixed Patient Groups

  • Autism spectrum disorder (ASD)
  • Neurodevelopmental disorder (NDD)
A group of different people.

2.

Patient Stratification

  • Clinical data
  • Multi-omics profiling
  • Systems biology
  • Data integration and analysis

3.

Subgroup Characterization: Clinical sign and symptoms (CSSs) and Cellular and molecular perturbations

  • Clinical sign and symptoms (CSSs)
  • Cellular and molecular perturbations

4.

AI Powered Drug Selection and Prioritization: On/off-target effects; Profile matching; IP potential

  • On/off-target effects
  • Profile matching
  • IP potential

5.

Patient Subgroup Specific Drug Candidate: Monotherapy and Combination treatments

  • Monotherapy
  • Combination treatments

Platform modules

Medication and magnified glass with arrow to a person and his DNA beeing examined.

Identify Promising Drug Candidates with Precision

  • Identify potential drug candidates or drug combinations with a high likelihood of efficacy based on their molecular profile
  • Prioritize drug candidates for further investigation, saving time and resource
  • Gain a deeper understanding of the underlying biological mechanisms driving the drug’s effect
Medication and three people one is feeling good, second is feeling dizzy and third feels no difference.

Characterize Actionable Clinical Signs and Symptoms

  • Identify clinical and morphological conditions associated with drug response
  • Uncover the biological pathways underlying drug efficacy and side effects
  • Develop more targeted and personalized treatment strategies
A group of different people and three arrows leading to subgroups created from them each subgroup with their medication.

Identify Patient Subgroups for Targeted Therapies

  • Identify specific patient subgroups who are most likely to benefit from a particular treatment
  • Develop more effective clinical trials by enrolling patients with the highest probability of response
  • Personalize treatment strategies based on individual patient characteristics